Contestants will be challenged to answer questions and solve problems as they are transported around the set in a specially designed, speeding capsule capable of rotating 360 degrees, a press release said.
What the winner goes home with has not been announced yet.
"Rob Lowe is the real deal. We're incredibly lucky to have someone so committed to quality, and who brings an unparalleled zeal to each of his projects," said Mike Darnell, president of Warner Bros.' unscripted and alternative television division, which is producing the project.
"He's the perfect partner for this new series that is a literal thrill ride for your brain."
"I've loved mental competition shows ever since. For me, 'Mental Samurai' is addicting. Every time you play, you think: THIS time I'm gonna win! But this very simple game is almost impossible to crack. Also, as a producer, I'm excited to get into this new arena," Lowe said.
FOLLOW REALITY TV WORLD ON THE ALL-NEW GOOGLE NEWS!
Reality TV World is now available on the all-new Google News app and website. Click here to visit our Google News page, and then click FOLLOW to add us as a news source!
This is not Lowe's first foray into unscripted television.
He and his sons appeared in the travel docu-series "The Lowe Files" and the actor was also the subject of a Comedy Central roast in 2016.
He has guest co-hosted "Live!" with Kelly Ripa, as well.
Producing and hosting a really cool new competition series, "Mental Samurai." If you like American Ninja Warrior AND mental challenges, you will love it! @FOXTV- Rob Lowe (@RobLowe) August 2, 2018
Copyright 2018 United Press International, Inc. (UPI). Any reproduction, republication, redistribution and/or modification of any UPI content is expressly prohibited without UPI's prior written consent.