"We can confirm that we have decided to separate, and this decision was made mutually and amicably. We kindly ask for privacy as we navigate this transition," the former "Pitch Perfect" co-stars said in a joint statement.
Camp, 36, and Astin, 31, have unfollowed each other on social media.
Astin last posted a photo of himself with Camp on Instagram on New Year's Day.
Camp and Astin started dating in 2013 after meeting on the set of "Pitch Perfect" in 2012.
They got married during an outdoor ceremony on the central California coast in September 2016.
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