U.S. media mogul Oprah Winfrey lends her voice to a character in an animated clip called "The O Show" for the 41st season premiere of "Sesame Street."

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The video is to appear on the episode of the iconic preschool program set to air Sept. 27 on PBS Kids.

Preschoolers and their caregivers will see the letter O host her own talk show with guests, including Otto the Orangutan and Ophelia the Octopus, to learn words that start with the letter, "Sesame Street" producers said in a news release Monday.

Fans can log on to http://www.youtube.com/sesamestreet to catch a sneak peek of "The O Show," as well as original celebrity appearances by Wanda Sykes, Jason Bateman, Kara DioGuardi, Rev Run, Chris O'Donnell, Colin Farrell and Katy Perry.