While the Giuliana & Bill star will remain a co-host of E!'s Live From the Red Carpet and Fashion Police, she's leaving her position as a daily anchor on E! News.
Rancic's departure will occur on Monday, August 10, according to E! News.
"For more than a decade, I was fortunate enough to play a role in the success of E! News and will miss my family at the show," Rancic said in a media statement.
"At the same time, I am excited to not only continue as host of two major franchises on E! but also executive produce the aspirational new show Rich in Faith for Oxygen as well as take my wine and clothing lines to the next level. This is such a thrilling time for me and I thank the gang at E! for understanding my desire to embark on this next chapter in my life."
Adam Stotsky, the general manager of E! and president of Esquire Network, had some kind words for Rancic.
"During her time here, Giuliana played an instrumental role in building E! News into a global entertainment news powerhouse and, while we will miss seeing her on set every day, we are delighted to continue to work with her on Fashion Police and Live From the Red Carpet," Stotsky added in a separate statement.
The TV personality joined E! News back in 2002 and began hosting in 2005. One year later, Ryan Seacrest came onboard and the pair co-hosted the show right up until 2011.
Fashion Police is scheduled to return August 31. Rancic will be starring on the series alongside Brad Goreski and the late Joan Rivers' daughter Melissa Rivers.