The series of 12 half-hour episodes will be produced by Kinetic Content, the new company run by Chris Coelen, whose TV credits include "Secret Millionaire."
"Betty White is a comedic genius who escalates hilarity in any situation," Telegdy said in a statement. "Viewers will thoroughly enjoy watching her pull one over on the unsuspecting youth of America."
"People have been telling me that I'm 'Off My Rocker' for years -- now I can prove it," added White.
"NBC is a terrific home for great comedy and Betty White's mischievous sense of humor is a perfect fit with this format which has shattered ratings expectations and garnered critical acclaim in every territory around the world," said Coelen, chief executive officer of Kinetic Content.