Janney, who just wrapped a seven-year run on NBC's "The West Wing," will take on the role of Prudy Pingleton, played by Jackie Hoffman on Broadway, Playbill.com reported.
The new "Hairspray" will include musical numbers from the stage show, which has garnered numerous Tony Awards.
Janney is no stranger to the Broadway stage. She has four Tony nominations under her belt, including one for her performance in a 1988 revival of Arthur Miller's "A View from the Bridge."
"Hairspray" is expected to hit the screens next summer.
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