"Star Trek has been an important part of UPN's history," she said, "and 'Enterprise' has carried on the tradition of its predecessors with great distinction."
Paramount Network Television President David Stapf left the door open for more "Star Trek" series.
"All of us at Paramount warmly bid goodbye to 'Enterprise,'" he said, "and we all look forward to a new chapter of this enduring franchise in the future."
In January, Paramount Domestic Television sold re-run rights for off-network syndication in more than 90 percent of the country, including 49 of the 50 top markets. The show is set to begin its syndication run this fall.