Lowe, 53, appeared on Monday's episode of the NBC late-night talk show with his two sons, 23-year-old Matthew Edward and 21-year-old John Owen, who co-host in A&E's new "The Lowe Files" reality series with him.
The "Best Son Challenge" saw Matthew and John play a version of "The Newlywed Game" where they answered questions about their dad.
Host Jimmy Fallon asked what Lowe's favorite movie is, what Lowe would wish for from a genie, what makes Lowe laugh the hardest, and what Lowe's hidden talent is.
Matthew and John both correctly identified their dad's favorite movie as "GoodFellas," but only Matthew guessed Lowe would wish "to live to be 100" or for "eternal life" from a genie.
The game ended up tied after Lowe acknowledged John introduced him to what makes him laugh the hardest, the show "Check It Out!" with Dr. Steve Brule.
Lowe shares Matthew and John with his wife, makeup artist Sheryl Berkoff, whom he married in 1991. His sons playfully roasted him during an appearance on "The Ellen DeGeneres Show" in May.
"He's a manchild," John said of his dad.
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"He's a teenager trapped in a 53-year-old's body. One of the worst things is if I'm in a crowd and he's anywhere nearby, he will scream at the top of his lungs my least favorite nicknames. And they're really embarrassing!"
"I will beg him sometimes: 'Like, just let me run your social media. I will do it for free, happily,' and yet he continues to occasionally mortify us," he added. "He likes selfies a little too much."
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