Kris Jenner's affair devastated her late ex-husband, Robert Kardashian, according to Khloe Kardashian.

Khloe, the former couple's youngest daughter, addressed her mom's infidelity on Wednesday's episode of "Kocktails with Khloe."

Kris went public with the affair in her 2012 memoir, which was published nine years after Robert's death.

"I love my mom but my mom cheated on my dad, which she's been honest about," Khloe said. "I think because of that and I saw how it destroyed my dad, I've never, ever cheated in any relationship."

"I just believe in being honest," she added. "Even if you're not feeling something -- you don't even have to want to cheat -- if you're just not fully invested in the relationship, I believe in being honest about that."

The discussion came just weeks after Khloe's split from NBA star James Harden.

The 31-year-old reality star claimed the 26-year-old Houston Rockets shooting guard was unfaithful in the same episode and said she will never cheat in a relationship.

"I just saw what it did to my dad and I was like, 'I don't want to do that,'" Khloe said. "But I appreciate those lessons and I also saw the regret from my mom. So I've never, ever cheated in my life. I don't believe it needs to be done."

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Kris and Robert were married from 1978 to 1991 and share three other children, Kourtney Kardashian, Kim Kardashian and Rob Kardashian. The 60-year-old reality star referred to her lover as "Ryan" in her memoir, but former soccer player Todd Waterman later came forward.

Robert was known for serving on O.J. Simpson's defense team and remained close with Kris until his death at age 59 in 2003.

Kris had nothing but good things to say about her late ex-husband in the March issue of Harper's Bazaar.

"I had a wonderful, beautiful life with Robert," she told the magazine. "He was just an amazing man. I always wish I could call Robert right now. That's an everyday thing.

Kris, Khloe and the rest of the Jenner-Kardashian family star on E! series "Keeping Up with the Kardashians," which will return from midseason break in the spring.