The 51-year-old comedian and former Saturday Night Live star was nowhere to be found on Wednesday evening's Celebrity Big Brother live feeds when they resumed following an outage, according toUs Weekly.
Chris' sudden disappearance has fans questioning if he tired of the game and quit prematurely or left for other undisclosed reasons, perhaps due to back pain since Chris had broken his neck years ago.
It appears, however, Chris' absence is not temporary, because according to the magazine, his fellow celebrity houseguests began talking about Chris as if he was no longer playing the game.
"I wasn't that stressed when Chris Kattan was still here because I felt like we had a chance for him to go home," rapper and dancer Todrick Hall reportedly said to former The Real Housewives of Atlanta star Cynthia Bailey.
"That has thrown a huge curveball in the game."
Cynthia added, "Yeah, because now it's, like, he's out of the equation."
CBS confirmed to Us that Chris' situation will be addressed during the upcoming Friday, February 11, episode on CBS.
Several hours after Chris was last spotted on the BB live feeds on Wednesday, a photo was posted on his Instagram account with the following caption: "I just met a girl named Maria! @maria_libri."
It's unclear whether Chris had made the post himself or if one of his friends or family members is still running his social-media accounts.
It probably wouldn't come as a surprise to Celebrity Big Brother viewers if Chris opted to leave the game only a couple of weeks in as he had actually campaigned for Olympic medalist Mirai Nagasu to remain in the game over him when he was facing eviction alongside Mirai a few days earlier.
Chris seemed willing to fall on the sword for Mirai, but it's also possible he may have just been looking for an out and a way to go home.
"I love you all and I think it's time for me to move on," Chris announced in his pre-eviction speech that aired on Monday, February 7.
"[Mirai], you've been very dedicated to playing the game and it's been very important to you, and I've seen that for a while -- a couple of weeks. You've had a lot of traumatic moments and I think you should stay."
Prior to entering the house, Chris admitted to Us that his biggest obstacle in playing the game would be the physical competitions, and he said he "did not watch a lot of Big Brother before being cast on the show" and so he probably didn't know what to expect.
This wouldn't be the first time a celebrity has wanted to quit the challenging Celebrity Big Brother game.
Former NBA player Metta World Peace attempted to get himself evicted early from Season 1, and then former White House communications director Anthony Scaramucci departed about a week into Season 2 -- only for host Julie Chen Moonves to later reveal a strange twist, that Anthony was never actually a real houseguest.
As the Celebrity Big Brother 3 game stands now, former UFC champion Miesha Tate is Head of Household for the second time and both Cynthia and designer and former Queer Eye star Carson Kressley are on the chopping block.
The next Celebrity Big Brother episode is set to air Friday, February 11 from 8-10ET/PT on CBS.