Flip It Like Disick is slated to debut this later this summer, although an official premiere date has yet to be announced for the eight-episode series.
"I'm excited to bring fans a new series that shows what I'm really passionate about professionally, which is flipping real estate and doing crazy and impressive renovations on celebrity homes," Disick said in a statement.
"E! has never had a show like this before. It's a bit different than viewers are used to seeing, but I think they will be both entertained and inspired by my team."
Disick's crew for the renovations will feature pop star-turned-interior designer Willa Ford, Disick's best friend and business partner Benny Luciano, contractor Miki Moor, and Disick's assistant Lindsay Diamond.
E! calls Disick's team, who will convert unique home projects for his celebrity friends and family, "dynamic, hilarious and headstrong."
Flip It Like Disick will show the personal and professional world of the father of three as he tackles high-end home flipping and remodeling.
Projects will include guest rooms, studios, and his children's playhouse at their mother Kourtney's home, as well as an ambitious multi-million dollar property in Los Angeles, CA.
Disick's passion for property development apparently began almost five years ago when he successfully flipped his first investment.
"Scott Disick is funny, unpredictable, and unfiltered," E! executive Amy Introcaso-Davis said in a statement.
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"Fans of Scott on Keeping Up with the Kardashians will get to see another side of him in Flip It Like Disick as an entrepreneur and design guru, leading his talented and opinionated team through difficult design challenges that result in astonishing reveals."
Disick was already talking about his new reality show back in Summer 2018.
"It will probably come out next year, and it's basically about me doing things that I'm interested in, which is buying and selling properties," Disick told People in July of last year.
"I guess it's cool that people will be able to see something that's a little bit different, and it's cool for me because it's something I'm passionate about."
Flip It Like Disick is being produced by STXtelevision with Tower 2 Productions and Ryan Seacrest Productions.