Anthony Jeselnik, a Comedy Central roast veteran, will serve as the series' new host.
"We are excited that Norm is joining Roseanne and Keenen in helping us find America's newest comedy star," NBC reality chief Paul Telegdy said in a statement. "This is a hugely talented and iconic panel. Anthony will add his unique quick-witted humor as the host of the show."
Last Comic Standing will continue to search for the funniest comic in the country and feature a variety of surprise celebrity guests along the way.
The new eight-episode season will begin with invitation-only auditions, and the Top 100 comics in America will vie for 40 spots. The talented 40 contestants will then compete in a semifinal round, with only the Top 10 moving forward into a new head-to-head round.
In the new head-to-head phase of the competition, the comics will be paired in a high stakes single-elimination round of stand-up standoffs.
The Top 5 comedians will then advance to the finals, and eventually one will be crowned the "Last Comic Standing" and receive a $250,000 prize package -- including a development deal for his or her own television show.