Formerly known as Bruce Jenner before her transgender transition nearly two years ago, Caitlyn also served as a stepdad to Kim, Khloe, Kourtney Kardashian and Rob Kardashian. The couple announced their separation in October 2013, and then Kris filed for divorce in September 2014.
"But yet, he stayed married to you the longest. So, it doesn't make sense," Kim, 36, notes in the preview clip.
"None of it makes sense," Kris replies. "Everything she says is all made up. Why does everything have to be that Kris is such a bitch and an assh-le?"
Kris then recalls a time when she had talked to Caitlyn about the former Olympic athlete's true identity while they were still together. (Several of Caitlyn's family members had caught Bruce cross-dressing before he decided to come out to the public as transgender).
"I was curious and said, 'What the hell is going on?'" Kris tells her girls. "She said, 'You just would never understand.' And then, all through the book, 'Kris knew. Kris knew before I even made love to her.' I'm like, 'What?'"
Kim and Khloe, 32, appear sympathetic during this conversation, as Caitlyn once painted Kris in an unflattering light when she opened up about her life-long secret in a June 2015 cover story for Vanity Fair.
"My mom's been putting in so much effort trying so hard to have a good relationship for their kids together," Kim explains in a confessional. "Caitlyn has every right to feel however she feels, but why bring my mom into it one more time? I just feel so bad for my mom."
"I really tried hard to improve the relationship and spend a little bit of time thinking, 'Maybe there's something here that I'm not seeing.' I've done nothing but open up my home and my heart to a person who doesn't give a sh-t. So, I'm done," Kris tells Kim and Khloe.
Kris then reveals to the cameras, "I'm not gonna be used as a person who benefits someone else's life just to make them look better. I just can't sit back and be an enabler anymore."
The preview clip concludes with Kris venting to her daughters about the situation.
"I've never been so angry and disappointed in somebody in my whole life," Kris says. "I'm done. Done! Dunzo. Sorry."