"God is so good!! I am beyond excited! What a blessing!!!!!!" the mom-of-six gushed.
Kardashian had confirmed the news Wednesday by posting a baby bump photo after months of speculation.
The 33-year-old reality star said motherhood is her "greatest dream realized."
"We are having a baby!" she wrote.
"I had been waiting and wondering but God had a plan all along. He knew what He was doing. I simply had to trust in Him and be patient. I still at times can't believe that our love created life!"
Model Bella Hadid and singer Cheryl were among the other stars to congratulate Kardashian on her pregnancy.
The pair shared their excitement in comments on the mom-to-be's pregnancy announcement.
"I am completely in tears Khlo I'm so happy for you you are going to be the best mama," Hadid wrote.
"Khloeeee!!! such amazing news. I could not be happier for you." Cheryl added.
"You gorgeous soul! You are about to have the best, most precious time of your life. And you truly deserve it. Congratulations Mommy. Wishing you a happy healthy pregnancy and what a wonderful way to start a new year."
Kardashian's sister Kylie Jenner is expected to announce her own pregnancy on the Kardashian family Christmas card.
The 20-year-old is reportedly expecting her first child with rapper Travis Scott.
Copyright 2017 United Press International, Inc. (UPI). Any reproduction, republication, redistribution and/or modification of any UPI content is expressly prohibited without UPI's prior written consent.