While the Racers may feel prepared and confident given they've already competed on a reality competition show before, Keoghan doesn't necessarily feel one team has a great advantage over another.
Chris, 40, and Bret, 44 are friends from Moore, OK, and Dedham, MA.
The guys met when they competed on Survivor: Millennials vs. Gen X.
"It's a really interesting dynamic. It's nice to see really good friends. Chris has got this intensity to him that is palpable. You can just see it," Keoghan toldParade magazine in a recent interview.
"At the starting line, he's champing at the bit to get going. Being a lawyer, you have to have that edge. There's a rough exterior to him when he's competing, but he's a real softie when you're just having a heart-to-heart with him."
Likewise, Keoghan compared Bret to "a big teddy bear."
"He looks tough, but you can't help but like him," Keoghan said.
"And he told me he's been really keen on going to New Zealand, which makes me like him even more."
Eliza, 35, and Corinne, 39, are friends from New York, NY, and Denver, CO.
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Eliza previously competed on Survivor: Vanuatu and Survivor: Micronesia -- Fans vs. Favorites.
Corinne previously competed on Survivor: Gabon and Survivor: Caramoan -- Fans vs. Favorites.
Keoghan was apparently surprised by what he learned once he got to know the couple.
"His wife is a lot softer as a personality. I like them. I thought they would have more gruff personalities. But the two of them together are a very sweet couple," Keoghan said.
Fans will find out how these pairs fare on The Amazing Race when 11 teams are tasked to complete mental and physical challenges throughout the race for $1 million to different destinations and countries across the world.
CBS has been highlighting the teams' differing experiences in its promotion for the season.
"Will the former Racers' travel experience be the most helpful?" CBS recently teased.
"Will the former Survivors outwit, outplay and outlast the competition? Or, will the Big Brother players' abilities to adapt and expect the unexpected make the difference?"