Chen announced in September she was leaving the show following her husband Leslie Moonves' exit as chief executive officer and chairman of CBS amid sexual misconduct allegations.
Inaba, who began her television career nearly three decades ago as one of the Fly Girls dancers on the sketch comedy show "In Loving Color," has filled in as a guest host on "The Talk" for the past two years.
"Everyone's Talking about it, and I'm excited to confirm it. We're welcoming Carrie Ann Inaba to 'The Talk' table," Angelica McDaniel, executive vice president of daytime programs for CBS Entertainment, said in a statement.
"Carrie Ann connects with audiences by being genuine. We appreciate her warmth, heart and vulnerability, and love what she brings to the show."
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