La La, 37, moved out of her shared home with Carmelo, 32, last week and is now living alone in New York City, TMZ reported.
The split followed seven years of marriage, as the couple tied the knot in July 2010 for a VH1 reality special La La's Full Court Wedding.
The reasons behind La La and Carmelo's breakup are unclear, but reports are swirling the Knicks player has been stressed out dealing with talks of a potential trade and La La is "pissed" that her husband allegedly cheated on her.
Multiple sources told TMZ that Carmelo got an exotic dancer pregnant who works at a gentleman's club in New York. The unidentified woman is reportedly requesting that Carmelo pay for her medical expenses and take care of additional costs for the baby.
The alleged pregnant dancer claims she is six-and-a-half months into her pregnancy and Carmelo is the father.
However, the pair's separation is reportedly amicable. La La and Carmelo were recently spotted attending their 10-year-old son Kiyan's basketball game together.
La La and Carmelo "have been fighting for about a year," a source close to the couple told the New York Daily News. "The marriage has always been a rocky one, so this is no surprise."
Neither individual has filed divorce papers yet, but according to TMZ, there is little-to-no chance of a reconciliation.
La La and Carmelo began dating in 2004 when she worked on the set of MTV's Total Request Live. They got engaged on Christmas Day in 2004, welcomed their only child in March 2007, and then waited a while before getting married.
La La, formally known as Alani Vazquez, and Carmelo starred on La La's Full Court Life together from August 2011 to July 2014.