House was born and raised in Jacksonville, Florida. House's father, a physician, is from Canada and her mother is from Mexico. From early childhood, House showed great interest in fashion, which she claims was spurred by her grandmother, saying:
" I was always in her closet. We would watch TV, read magazines, go to the mall. She taught me about couture and how important it was. A lot of my appreciation came from her".
After graduating from Bishop Kenny High School in 1998, House attended the University of North Florida, majoring in international relations and Asian studies. House speaks fluent Japanese as well as Spanish (which she spoke from a young age). Around this time, House also began to pursue a career in fashion modeling, but claimed she found her options limited because she was overweight. She says she eventually lost 45 pounds after changing her diet and adopting an exercise plan.
Her son Alastair was born in August 2008.
She lives in New York City with her husband and son.
House was the winner of Cycle 2 of America's Next Top Model. After Top Model, she signed with IMG Models. House made her debut as a runway model at the Mercedes-Benz Fashion Week in 2004, walking for fashion designers Petro Zillia, Custo Barcelona, Sue Wong, and John Sakalis. She took place in a promotional runway show for America's Next Top Model Obsessed which premiered on Oxygen. Her most visible modeling assignments immediately after her win include a commercial for the Declare Yourself voting campaign, a cover story for Psychology Today magazine., spread in Hannah Anderson, Jane, Look for Less Ads, Metro Style, Careline, Jacksonville which she had a cover and spread,Sue Wong 2005 Line, The August 2010 edition of Jacksonville. She became host of The Look for Less in 2005, replacing Elisabeth Hasselbeck.
The following year, House was named "the face" of The CW network and appeared in commercials and web advertisements for the fledgling network. In overseas projects, she signed with Danish modeling agency 1st Opinion Model Management and won a contract with Careline, an Israeli cosmetics company. She appeared in a commercial for make-up brand Sheer Cover, Leeza Gibbons's make-up line, along with Cycle 4 winner of America's Next Top ModelNaima Mora.
In the summer of 2008, House hosted The N's reality series Queen Bees, which attempts to reform mean girls. She has also filmed a PSA for Declare Yourself, parodying a lipstick commercial.