You, Me and Dupree is a 2006 American romantic comedy film directed by Anthony Russo and Joe Russo, written by Mike LeSieur, and produced by Mary Parent, Scott Stuber, and Owen Wilson.
The film revolves around newlyweds Carl and Molly Peterson (Matt Dillon and Kate Hudson). After Carl's best man and friend Randolph Dupree (Owen Wilson) loses his job and apartment, the couple allow him to move in but Dupree inevitably overstays his welcome.