The Wayans Brothers. is a situation comedy that aired from January 1995 to May 1999 on The WB. The series starred real-life brothers Shawn Wayans and Marlon Wayans. Both brothers were already well-known from the sketch comedy show In Living Color that was aired from 1990 to 1994. The series also starred John Witherspoon and Anna Maria Horsford (season 2 onward).