The show depicted how humanity has colonized the solar system.
Mark Fergus and Hawk Ostby served as showrunners.
"'The Expanse' transported us across the solar system for three brilliant seasons of television. Everyone at Syfy is a massive fan of the series, and this was an incredibly difficult decision," president of entertainment networks at NBCU Cable Entertainment Chris McCumber said in a statement.
"We want to sincerely thank 'The Expanse's amazing cast, crew and all the dedicated creatives who helped bring James S.A. Corey's story to life. And to the series' loyal fans, we thank you most of all."
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