Michael Fishman and his wife Jennifer Briner filed for divorce this week after 19 years of marriage.
They have another child who is legally an adult.
Briner cited "irreconcilable differences" as the reason the marriage was ending, said UsMagazine.com.
The "Roseanne" and "The Conners" actor told TMZ he and his estranged wife have been in the process of amicably splitting up since June 2017.
Fishman and the original cast returned for a revival this year, but the show was canceled after its star Roseanne Barr made racially charged remarks on Twitter.
A spinoff called "The Conners" and starring the entire "Roseanne" ensemble except for Barr is now running on ABC.