Sources told TMZ the 30-year-old actress and 31-year-old singer spent time at the Republic Records Grammys after-party at Hyde nightclub before leaving the venue together.
"She was really happy, you can see it," an eyewitness told E! News. "It looked like they completely hit it off and were trying to downplay the flirtation as friendship but it was pretty undeniable. Kaley kept talking to him with her hand over her mouth."
Cuoco filed for divorce from husband Ryan Sweeting in September after less than two years of marriage. She denied she and ex-boyfriend Johnny Galecki reconciled again in January after attending the People's Choice Awards with her Big Bang Theory co-star.
Hunt previously dated Hannah Lee Fowler, but largely keeps his romances out of the spotlight. He told E! News there "aren't really any specific qualities" he looks for in a woman while discussing his personal life in 2014.
"I just have an open mind to a person that I will connect with in a very unique way," he said. "I kind of like that I don't even know what those qualities are. It's more about just an invisible connection that you can't put your finger on."
Cuoco is best known for playing Penny on CBS sitcom "The Big Bang Theory," which airs Thursdays at 8 p.m. ET. Hunt released his debut studio album, Montevallo, in 2014, and was nominated for Best County Album and Best New Artist at the Grammys.
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