According to Spider-Man mythology, Peter dates Mary Jane after his romance with Gwen ends.
The Hollywood Reporter said Mary Jane will now be introduced in the next movie, but the role will likely be played by another actress.
"Of course, I'm bummed," Woodley told EW.com. "But I'm a firm believer in everything happening for a specific reason ... based on the proposed plot, I completely understand holding off on introducing [Mary Jane] until the next film."
Woodley, 21, is best known for her Oscar-nominated performance in "The Descendants" and her work on TV's "Secret Life of the American Teenager."