Set to debut in 2018, the eight-episode series is about a psychopathic assassin and the woman charged with hunting her down.
"I am quivering with excitement about working with Sandra! I have been a huge fan of hers forever and am pinching myself that she is playing our Eve. She is going to be so badass in this role," showrunner Phoebe Waller-Bridge said in a statement.
"Sandra Oh has the ability to go from wrenching to funny to total mess with a genius lightness of touch. Phoebe's vision is absolutely original, and Sandra is utterly perfect casting we think for this key role," added Sarah Barnett, president of BBC America.
The cable network has not announced who will play the assassin in the series, which is based on the novellas by Luke Jennings.
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