Ne-Yo achieved total chart domination Thursday with his single "So Sick" atop the Billboard Hot 100, Top 100 and Hot Digital Songs charts.
His album, "In My Own Words," was anointed No. 1 on The Billboard 200 only the day before.
Last week's No. 1 single, James Blunt's "You're Beautiful," fell to No. 3 on the Hot 100, but ended Lifhouse's seven week run atop Billboard's Adult Contemporary chart.
The No. 2 spot on the Hot 100 was Sean Paul's "Temperature" while Mary J. Blige's "Be Without You" moved up to No. 4 and held on to No. 1 on the R&B/Hip-Hop Songs chart for its 11th week.
Beyonce's "Check on It" featuring Slim Thug was No. 5, T-Pain's "I'm N Luv (Wit a Stripper)" featuring Mike Jones held onto No. 6 and Nelly's "Grillz" featuring Paul Wall, Ali & Gipp clocked in at No. 7.
Chris Brown's "Yo (Excuse Me Miss)" dropped to No. 8, while Dem Franchize Boyz' "Lean Wit It, Rock Wit It" featuring Lil Peanut & Charlay was No. 9 and Natasha Bedingfield's "Unwritten" filled out the Top 10.
Kenny Chesney's "Living in Fast Forward" moved up to No. 1 on the Hot Country Songs chart while Daddy Yankee's "Rompe" topped Hot Latin Songs chart for its 14th week.