U.S. cancer survivors Christina Applegate, Lance Armstrong and Fran Drescher are to take part in the upcoming Stand Up to Cancer fundraiser, organizers said.

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The one-hour program is to be simulcast Sept. 10 live

and commercial-free on ABC, CBS, FOX, NBC, Bio, Discovery Health, E!, G4, HBO, HBO Latino, MLB Network, mun2, Showtime, Smithsonian Channel, The Style Network, TV One, and VH1.

Executive produced by Laura Ziskin, the special will feature as hosts Katie Couric, Diane Sawyer and Brian Williams -- the anchors, respectively, of the CBS, ABC and NBC evening news programs.

Also expected to participate are Elizabeth Edwards, Delta Goodrem, Michael C. Hall, Kareem Abdul-Jabbar, Sharon Osbourne, Robin Roberts, Maura Tierney, Sofia Vergara, Marissa Jaret Winokur and Ethan Zohn.

One of the musical performances will be an all-star collaboration led by Stevie Wonder with Natasha Bedingfield, Queen Latifah, Martina McBride, Aaron Neville and Dave Stewart.

"We are eternally grateful for the remarkable support we've received from the entire entertainment community. We couldn't do this without everyone's help -- from the networks and cable channels donating the airtime to our celebrity volunteers participating in the show and a lot of other people in between," Sherry Lansing, one of the co-founders of Stand Up to Cancer, said in a statement Thursday.

"On Sept. 10, we'll send a resounding message: we can cure cancer. It's going to take guts, brains, and the ongoing support of the public, but we can do this ... No donation is too small -- every single person can play a role in helping the scientists who are working 24/7 to end cancer," added Ziskin, co-founder and executive producer of the Stand Up to Cancer telecast.