The two-time Daytime Emmy Award winner taped his last episode in the role of Will last Friday, EW.com said.
The name of his replacement has not been disclosed yet.
"As Chandler Massey announced back in June, he will be leaving the show to further pursue his education and other entertainment opportunities," a statement from the NBC show said.
"While 'Days of Our Lives' is disappointed to lose such a talent, the show understands and supports him in his future endeavors. Due to current storyline and the timely discovery of new talent that the show feels is the right recast for Will Horton, a mutual decision has been made for the changes to taken place immediately. Chandler will always be a part of the Days family and we wish him nothing but continued success."
"I'm done. It's bittersweet. These four years have been so amazing. I've built a family here. I'm so grateful to everyone for these amazing four years," Massey said in a separate statement on his last day at "Days."