The French actor and Italian actress have been together 17 years, married for 14 and have two daughters -- Deva, 8, and Leonie, 3.
People.com said both of their representatives confirmed the breakup, with Cassel's saying the separation is "by mutual agreement."
No reason was given for the surprise split.
DISCUSS AND COMMENT ON THIS STORY Reality TV World now offers Facebook Comments on our stories. To post a comment, log into Facebook and then 'Add' your comment. To report spam or abuse, click the 'X' in the upper right corner of the comment box.