Ashley Greene's publicist told UsMagazine.com one of the actress' two toy fox terriers died in a fire at her West Hollywood condo Friday morning.
No humans were seriously hurt in the fire and Greene's second pup survived.
"She loves her dogs. LOVES," a source told UsMagazine.com. "She must be absolutely devastated."
There was no word on the cause of the fire.
Greene is best known for her work in the "Twilight" film franchise.