Foresight Unlimited in association with Castle Rock announced Wednesday production had officially begun.
The film marks the first time Douglas and Keaton have appeared on-screen together. Reiner previously collaborated with Douglas on the hit 1995 film "The American President."
Joining the cast in a pivotal supporting role is Sterling Jerins, a young actress who will soon be seen in the movies "The Conjuring" and "World War Z."
"Oren is a self-centered real-estate agent who couldn't care less about anyone else," said a synopsis of "And So It Goes..."
"But Oren's life is turned upside down when his estranged son suddenly drops off a granddaughter he never knew. Now, with the help of his determined and loveable neighbor, Leah, Oren stubbornly learns to care, and unexpectedly, to fall in love again."