The series is billed as the first game show in which two hosts duel to deceive contestants. It is to premiere in late 2013.
"This is a game show where a host is legitimately trying to convince a contestant to choose the wrong answer," producer Mark Burnett said in a statement. "D.L. and Michael's comedic styles are perfect for pulling this off. The comedy itself will be must-see television."
"It's great to have D.L. Hughley and Michael Ian Black on board for TBS' 'Trust Me, I'm a Game Show Host,'" said Michael Wright, president and head of programming for TBS, TNT and Turner Classic Movies.
"They possess the comedic instincts, sharp improvisational skills, sense of fun and easygoing charm necessary to earn the trust of contestants in this clever, one-of-a-kind game show from Mark Burnett, Will MacDonald and David Granger."